IDEXX SDMA testing

What to do when SDMA is increased

An increased SDMA may detect acute or early chronic disease within the kidneys or reflect abnormalities in other organ systems that impact kidney function.

The IDEXX SDMA Test Algorithm will help you take the appropriate steps towards confirming disease and diagnosis when SDMA is increased.

Interpret your SDMA results

Download: IDEXX SDMA Test Algorithm

IDEXX SDMA algorithm and IMM protocol

When SDMA is increased and other results look normal

SDMA provides deeper insights than creatinine and BUN alone.

Bess, a cat with CKD whose examination parameters were within normal limits, had an increased SDMA result. Learn more about how SDMA detects kidney disease in cats. 

Read this case study

Follow the IRIS guidelines for staging and treating CKD

Overview of the International Renal Interest Society (IRIS) guidelines for Chronic Kidney Disease (CKD)

The International Renal Interest Society (IRIS) chronic kidney disease (CKD) guidelines recognize the importance of SDMA for both diagnosis and treatment.6

Learn more about the guidelines

Tip: Share this Pet Health Network resource with clients

6 Surprising Facts About Kidney Disease in Cats

Answers to common questions about increased SDMA

If the SDMA concentration is increased on the preanesthetic screen for an elective procedure, it’s recommended to follow the IDEXX SDMA Test Algorithm to determine if kidney disease is probable and what investigation, management, and monitoring is recommended. 

Early diagnosis provides the opportunity to take action by doing the following:

  • Investigate for an underlying cause of kidney disease, especially more treatable conditions.
  • Manage or treat any underlying causes or confounding conditions and implement practices to avoid future insults to the kidneys.
  • Monitor the patient as indicated based on treatments initiated for any identified underlying diseases or confounding conditions.

Persistently increased SDMA in a hydrated patient is specific for kidney disease. SDMA correlates strongly with glomerular filtration rate (GFR) and increases when GFR is reduced. Therefore, if GFR is reduced with prerenal or postrenal azotemia, then SDMA will increase accordingly.

Approximately 26% of cats have an increased SDMA. Prevalence increases with age.7

Approximately 11% of dogs have an increased SDMA. Prevalence increases with age.7

Kidney disease is common, with 1 in 3 cats8 and 1 in 10 dogs9 developing some form of kidney disease over their lifetimes. 

Get more answers from our SDMA FAQs

Two options: same reliable results

The in-house Catalyst SDMA Test for use with the Catalyst One and Catalyst Dx chemistry analysers
The IDEXX SDMA Test, included with every chemistry panel or as a stand-alone test from IDEXX Reference Laboratories

References

  1. Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802.
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814.
  6. International Renal Interest Society. 2015 IRIS CKD Staging Guidelines. www.iris-kidney.com/guidelines. Accessed May 9, 2018.
  7. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
  8. Lulich JP, Osborne CA, O'Brien TD, Polzin DJ. Feline renal failure: questions, answers, questions. Compend Contin Educ Pract Vet. 1992;14(2):127–153.
  9. Brown SA. Renal dysfunction in small animals. The Merck Veterinary Manual website. www.merckvetmanual.com/urinary_system/noninfectious_diseases_of_the_urinary_system_in_small_animals/renal_dysfunction_in_small_animals. Updated October 2013. Accessed May 9, 2018.